New Spectrophotometric Methods for Estimation of Ethacridine Lactate in Pharmaceuticalformulations
نویسندگان
چکیده
Two simple and sensitive spectrophotometric methods (Method A and Method B) were developed for the estimation of Ethacridine lactate in pharmaceutical formulations. Method A is based on the oxidative coupling of Eathacridine Lactate with 3-methyl-2-benzothiazolinone hydrazone in the presence of Fe(III) to form a violet coloured chromoscme with a absorption maximum of 535nm. Method B is based on diazocoupling reaction with N-(1-napthyl) ethylenediamine dihydrochloride (B.M reagent) to form a stable purple coloured chromogen, which can be estimated at 540nm. Both the proposed methods (Method A and Method B) obey Beer’s law in the concentration range of 2 to 8μg/ml. The methods were validated for use in routine quality control of Ethacridine lactate in pharmaceutical formulations.
منابع مشابه
Spectrophotometric determination of ethacridine lactate in infusion
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